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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE3A
All Species:
10
Human Site:
Y592
Identified Species:
18.33
UniProt:
Q14432
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14432
NP_000912.3
1141
124979
Y592
C
S
S
C
G
R
P
Y
S
Q
G
N
P
A
D
Chimpanzee
Pan troglodytes
XP_520783
1141
125048
Y592
C
S
S
C
G
R
P
Y
S
Q
G
N
P
A
D
Rhesus Macaque
Macaca mulatta
XP_001096963
1141
124707
Y592
C
S
S
C
G
R
P
Y
S
Q
G
N
P
A
D
Dog
Lupus familis
XP_854529
779
87136
E311
L
T
E
E
A
Q
N
E
P
Q
P
N
I
E
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z0X4
1141
124494
G589
S
V
I
C
S
S
C
G
R
P
Y
S
Q
G
N
Rat
Rattus norvegicus
Q62865
1141
124282
G589
P
V
I
C
S
S
C
G
R
P
Y
S
Q
G
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518516
340
38206
Chicken
Gallus gallus
XP_416416
825
91797
K357
P
L
I
P
P
E
D
K
P
V
L
A
P
E
P
Frog
Xenopus laevis
NP_001088828
985
108702
D517
Q
E
S
R
L
Q
K
D
S
R
N
E
P
G
G
Zebra Danio
Brachydanio rerio
XP_695432
1117
123518
S526
P
P
P
T
P
L
C
S
S
C
G
R
P
Y
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9W4T4
1209
129395
V527
L
A
N
V
R
F
D
V
E
N
G
Q
G
A
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q8I0P7
625
69850
I157
S
K
P
R
I
S
N
I
T
F
S
T
V
T
S
Sea Urchin
Strong. purpuratus
XP_793920
1558
171759
V932
T
I
T
P
D
D
A
V
K
D
A
S
E
N
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
97.5
38.2
N.A.
84
84.6
N.A.
20.9
59.6
43.9
57.8
N.A.
20.8
N.A.
26.7
29.9
Protein Similarity:
100
99.7
98.4
49.6
N.A.
89.3
90
N.A.
25.1
63.9
58.3
71.2
N.A.
36.3
N.A.
37.9
43.2
P-Site Identity:
100
100
100
13.3
N.A.
6.6
6.6
N.A.
0
6.6
20
20
N.A.
13.3
N.A.
0
0
P-Site Similarity:
100
100
100
26.6
N.A.
20
20
N.A.
0
6.6
33.3
20
N.A.
26.6
N.A.
6.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
8
0
8
0
0
0
8
8
0
31
0
% A
% Cys:
24
0
0
39
0
0
24
0
0
8
0
0
0
0
0
% C
% Asp:
0
0
0
0
8
8
16
8
0
8
0
0
0
0
24
% D
% Glu:
0
8
8
8
0
8
0
8
8
0
0
8
8
16
0
% E
% Phe:
0
0
0
0
0
8
0
0
0
8
0
0
0
0
0
% F
% Gly:
0
0
0
0
24
0
0
16
0
0
39
0
8
24
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
8
24
0
8
0
0
8
0
0
0
0
8
0
0
% I
% Lys:
0
8
0
0
0
0
8
8
8
0
0
0
0
0
0
% K
% Leu:
16
8
0
0
8
8
0
0
0
0
8
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
0
0
0
16
0
0
8
8
31
0
8
16
% N
% Pro:
24
8
16
16
16
0
24
0
16
16
8
0
47
0
8
% P
% Gln:
8
0
0
0
0
16
0
0
0
31
0
8
16
0
8
% Q
% Arg:
0
0
0
16
8
24
0
0
16
8
0
8
0
0
8
% R
% Ser:
16
24
31
0
16
24
0
8
39
0
8
24
0
0
16
% S
% Thr:
8
8
8
8
0
0
0
0
8
0
0
8
0
8
0
% T
% Val:
0
16
0
8
0
0
0
16
0
8
0
0
8
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
24
0
0
16
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _